odor memory stability after reinnervation of the olfactory bulb气味嗅球神经移植后内存稳定.pdfVIP

Odor Memory Stability after Reinnervation of the Olfactory Bulb ´ 1 1 2 ´ ´ 1 Eduardo Blanco-Hernandez , Pablo Valle-Leija , Viviana Zomosa-Signoret , Rene Drucker-Colın , ´ 3* Roman Vidaltamayo ´ ´ ´ ´ ´ 1 Departamento de Neuropatologıa Molecular, Instituto de Fisiologıa Celular, Universidad Nacional Autonoma de Mexico, Distrito Federal, Mexico, 2 Departamento de ´ ´ ´ ´ ´ ´ ´ Bioquımica, Facultad de Medicina, Universidad Autonoma de Nuevo Leon, Nuevo Leon, Mexico, 3 Departamento de Ciencias Basicas, Centro de Diagnostico Molecular y ´ ´ Medicina Personalizada, Universidad de Monterrey, Nuevo Leon, Mexico Abstract The olfactory system, particularly the olfactory epithelium, presents a unique opportunity to study the regenerative capabilities of the brain, because of its ability to recover after damage. In this study, we ablated olfactory sensory neurons with methimazole and followed the anatomical and functional recovery of circuits expressing genetic markers for I7 and M72 receptors (M72-IRES-tau-LacZ and I7-IRES-tau-GFP). Our results show that 45 days after methimazole-induced lesion, axonal projections to the bulb of M72 and I7 populations are largely reestablished. Furthermore, regenerated glomeruli are re-formed within the same areas as those of control, unex