resection of nonalcoholic steatohepatitis-associated hepatocellular carcinoma a western experience切除的非酒精性肝细胞癌steatohepatitis-associated西方经验.pdfVIP

Hindawi Publishing Corporation International Journal of Surgical Oncology Volume 2012, Article ID 915128, 7 pages doi:10.1155/2012/915128 Research Article Resection of Nonalcoholic Steatohepatitis-Associated Hepatocellular Carcinoma: A Western Experience Brian Shrager,1 Ghalib A. Jibara,1 Parissa Tabrizian,1 Sasan Roayaie,1 and Stephen C. Ward2 1 Division of Surgical Oncology, Department of Surgery, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1259, New York, NY 10029, USA 2 Department of Pathology, Mount Sinai School of Medicine, 1468 Madison Avenue, Annenberg Building, 15th Floor, Room 92, New York, NY 10029, USA Correspondence should be addressed to Brian Shrager, shragermd1@ Received 22 May 2012; Accepted 31 July 2012 Academic Editor: S. Curley Copyright © 2012 Brian Shrager et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Introduction. Hepatocellular carcinoma is now known to arise in association with nonalcoholic steatohepatitis. The aim of this study is to examine the clinicopathological features of this entity using liver resection cases at a large Western center. Methods. We retrospectively reviewed all cases of partial liver resection for hepatocellular carcinoma over a 10-year period. We included for the purpose of this study patients with histological evidence of nonalcoholic steatohepatitis and excluded patients with other chronic liver diseases such as viral hepatitis and alcoholic liver disease. Results. We identified 9 cases in which malignancy developed against a parenchymal background of histologically-active nonalcoholic steatohepatitis. The median age at diagnosis