role of peroxisome proliferator-activated receptor gamma and its ligands in the treatment of hematological malignancies过氧物酶体的作用proliferator-activatedγ受体及其配体血液恶性肿瘤的治疗.pdfVIP

Hindawi Publishing Corporation PPAR Research Volume 2008, Article ID 834612, 18 pages doi:10.1155/2008/834612 Review Article Role of Peroxisome Proliferator-Activated Receptor Gamma and Its Ligands in the Treatment of Hematological Malignancies Tatiana M. Garcia-Bates,1 Geniece M. Lehmann,2 Patricia J. Simpson-Haidaris,1, 3, 4 Steven H. Bernstein,3, 5 Patricia J. Sime,2, 3, 6 and Richard P. Phipps1, 2, 3, 6 1 Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA 2 Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA 3 Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA 4 Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA 5 The Lymphoma Biology Program of James P. Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA 6 The Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA Correspondence should be addressed to Richard P. Phipps, richard phipps@ Received 17 March 2008; Accepted 21 April 2008 Recommended by Dipak Panigrahy Peroxisome proliferator-activated receptor gamma (PPARγ) is a multifunctional transcription factor with important regulatory roles in inflammation, cellular growth, differentiation, and apoptosis. PPARγ is expressed in a variety of immune cells as well as in numerous leukemias and lymphomas. Here, we review recent studies that provide new insights into the mechanisms by which PPARγ ligands influence hematological malignant cell growth, differentiation, and survival