nuclear envelope remnants fluid membranes enriched in sterols and polyphosphoinositides核被膜残余流体膜富含植物固醇和polyphosphoinositides.pdfVIP

Nuclear Envelope Remnants: Fluid Membranes Enriched in STEROLS and Polyphosphoinositides 1,3,5 1,4 1 2 Marie Garnier-Lhomme , Richard D. Byrne , Tina M. C. Hobday , Stephen Gschmeissner , Rudiger 3 4 5 ´ 1 Woscholski , Dominic L. Poccia , Erick J. Dufourc , Banafshe Larijani * 1 Cell Biophysics Laboratory, Lincoln’s Inn Fields Laboratories, Cancer Research UK, London, United Kingdom, 2 Electron Microscopy Unit, Lincoln’s Inn Fields Laboratories, Cancer Research UK, London, United Kingdom, 3 Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom, 4 Department of Biology, ´ Amherst College, Amherst, Massachusetts, United States of America, 5 UMR 5248 CNRS-Universite Bordeaux 1-ENITAB, IECB, Pessac, France Abstract Background: The cytoplasm of eukaryotic cells is a highly dynamic compartment where membranes readily undergo fission and fusion to reorganize the cytoplasmic architecture, and to import, export and transport various cargos within the cell. The double membrane of the nuclear envelope that surrounds the nucleus, segregates the chromosomes from cytoplasm and regulates nucleocytoplasmic transport through pores. Many details of its formation are still unclear. At fertilization the sperm devoid of nuclear envelope pores enters the egg. Although most of the sperm nuclear envelope disassembles, remnants of the envelope at the acrosomal and centriolar fossae do not and are subsequently incorporated into the newly forming male pronuclear envelope. Remnants are conserved from annelid to mammalian s