selected extracts of chinese herbal medicines their effect on nf-κb, pparα and pparγ and the respective bioactive compounds选择中国草药提取影响nf-κb,pparαpparγ和相应的生物活性化合物.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 983023, 10 pages doi:10.1155/2012/983023 Research Article Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds E. Rozema,1 A. G. Atanasov,1 N. Fakhrudin,1, 2 J. Singhuber,1 U. Namduang,1 E. H. Heiss,1 G. Reznicek,1 C. W. Huck,3 G. K. Bonn,3 V. M. Dirsch,1 and B. Kopp1 1 Department of Pharmacognosy, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria 2 Department of Pharmaceutical Biology, Faculty of Pharmacy, Gadjah Mada University, Sekip Utara, Yogyakarta 55281, Indonesia 3 Institute of Analytical Chemistry and Radiochemistry, University of Innsbruck, Innrain 52a, 6020 Innsbruck, Austria Correspondence should be addressed to B. Kopp, brigitte.kopp@univie.ac.at Received 21 February 2012; Accepted 13 March 2012 Academic Editor: Olumayokun A. Olajide Copyright © 2012 E. Rozema et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Chinese herbal medicinal (CHM) extracts from fourteen plants were investigated in cell-based in vitro assays for their effect on nuclear factor κB (NF-κB), a key regulator of inflammation, as well as on peroxisome proliferator-activated receptors (PPARs) being key regulators of genes involved in lipid and glucose metabolism. 43% of the investigated CHMs showed NF-κB inhibitory and 50% PPARα and PPARγ activating effects. Apolar extracts from cortex and flos of Albizia julibrissin Durazz. and processed rhizomes of Arisaema sp. and Pinellia ternata (Thunb.) Breit. that effectively inhibited TNF-α-induced NF-κB act