reproductive benefit of oxidative damage an oxidative stress “malevolence”生殖的氧化损伤的氧化应激u201c恶意u201d.pdfVIP

Hindawi Publishing Corporation Oxidative Medicine and Cellular Longevity Volume 2011, Article ID 760978, 9 pages doi:10.1155/2011/760978 Review Article Reproductive Benefit of Oxidative Damage: An Oxidative Stress “Malevolence”? B. Poljsak,1 I. Milisav,1, 2 T. Lampe,1 and I. Ostan3 1 Laboratory for Oxidative Stress Research, Faculty of Health Sciences, University of Ljubljana, Zdravstvena Pot 5, 1000 Ljubljana, Slovenia 2 Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia 3 Faculty for Maritime Studies and Transportation, University of Ljubljana, 1000 Ljubljana, Slovenia Correspondence should be addressed to B. Poljsak, borut.poljsak@zf.uni-lj.si Received 5 May 2011; Revised 9 June 2011; Accepted 28 July 2011 ´ Academic Editor: Jose L. Quiles Copyright © 2011 B. Poljsak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. High levels of reactive oxygen species (ROS) compared to antioxidant defenses are considered to play a major role in diverse chronic age-related diseases and aging. Here we present an attempt to synthesize information about proximate oxidative processes in aging (relevant to free radical or oxidative damage hypotheses of aging) with an evolutionary scenario (credited here to Dawkins hypotheses) involving tradeoffs between the costs and benefits of oxidative stress to reproducing organisms. Oxidative stress may be considered a biological imperfection; therefore, the Dawkins’ theory of imperfect adaptation of beings to environment was applied to the role of oxidative stress in processes like famine and