no consistent effect of adrb2 haplotypes on obesity, hypertension and quantitative traits of body fatness and blood pressure among 6,514 adult danesadrb2效果不一致的单体型肥胖、高血压和定量特征的身体肥胖,血压6514名成人的丹麦人.pdfVIP

No Consistent Effect of ADRB2 Haplotypes on Obesity, Hypertension and Quantitative Traits of Body Fatness and Blood Pressure among 6,514 Adult Danes 1 1 2,6 3,4 1,3,6 Anette P. Gjesing *, Thomas Sparsø , Knut Borch-Johnsen , Torben Jørgensen , Oluf Pedersen , Torben Hansen1,7, Niels V. Olsen3,5 1 Hagedorn Research Institute, Gentofte, Denmark, 2 Steno Diabetes Center, Gentofte, Denmark, 3 Institute of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark, 4 Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark, 5 Department of Neuroanaesthesia, Copenhagen University Hospital, Copenhagen, Denmark, 6 Faculty of Health Science, University of Aarhus, Aarhus, Denmark, 7 Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark Abstract Background: Evidence regarding the association of variation within ADRB2, the gene encoding the beta-adrenergic receptor 2 (ADRB2) with obesity and hypertension is exceedingly ambiguous. Despite negative reports, functional impacts of individual genetic variants have been reported. Also, functional haplotypes as well as haplotype combinations affecting expression levels in vivo of ADRB2 mRNA and protein as well as receptor sensitivity have been reported. The aim of the present study was therefore to evaluate if variations within ADRB2 as haplotypes or as haplotype combinations confer an increased prevalence of obesity and hypertension among adults. Methodology/Principal Findings: We genotyped five variants required to capture common variation in a region including the ADRB2 locus in a population-based study of 6,514 unrelated, middle-