no evidence for xmrv in german cfs and ms patients with fatigue despite the ability of the virus to infect human blood cells in vitro没有证据表明德国的xmrv cfs和疲劳患者尽管女士的能力病毒感染人类血液细胞体外.pdfVIP

No Evidence for XMRV in German CFS and MS Patients with Fatigue Despite the Ability of the Virus to Infect Human Blood Cells In Vitro 1,5 2 3 1 1 Oliver Hohn , Kristin Strohschein , Alexander U. Brandt , Sandra Seeher , Sandra Klein , Reinhard 4 3 2 2. 1,5 . Kurth , Friedemann Paul , Christian Meisel , Carmen Scheibenbogen , Norbert Bannert * ´ ¨ 1 Centre for Biological Security 4, Robert Koch-Institute, Berlin, Germany, 2 Institute for Medical Immunology, Charite - Universitatsmedizin Berlin, Berlin, Germany, ´ ¨ 3 NeuroCure Clinical Research Center (NCRC), Charite Universitatsmedizin Berlin, Berlin, Germany, 4 Robert Koch-Institute, Berlin, Germany, 5 Centre for Retrovirology, Robert Koch-Institute, Berlin, Germany Abstract Background: Xenotropic murine leukemia virus-related virus (XMRV), a novel human retrovirus originally identified in prostate cancer tissues, has recently been associated with chronic fatigue syndrome (CFS), a disabling disease of unknown etiology affecting millions of people worldwide. However, several subsequent studies failed to detect the virus in patients suffering from these illnesses or in healthy subjects. Here we report the results of efforts to detect antibody responses and viral sequences in samples from a cohort of German CFS and relapsing remitting multiple sclerosis (MS) patients with fatigue symptoms.