no association of the bdnf val66met polymorphism with implicit associative vocabulary and motor learning没有联系的bdnf val66met多态性与内隐联想词汇和运动学习.pdfVIP

No Association of the BDNF Val66met Polymorphism with Implicit Associative Vocabulary and Motor Learning 1 1 2 ¨ 2 2 Nils Freundlieb , Stephan Philipp , Susanne A. Schneider , Norbert Bruggemann , Christine Klein , 1 1 Christian Gerloff , Friedhelm C. Hummel * 1 Brain Imaging and Neurostimulation (BINS) Laboratory, Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 2 Schilling Section of Clinical and Molecular Neurogenetics, Department of Neurology, University of Luebeck, Luebeck, Germany Abstract Brain-derived neurotrophic factor (BDNF) has been suggested to play a major role in plasticity, neurogenesis and learning in the adult brain. The BDNF gene contains a common val66met polymorphism associated with decreased activity-dependent excretion of BDNF and a potential influence on behaviour, more specifically, on motor learning. The objective of this study was to determine the influence of the BDNF val66met polymorphism on short-term implicit associative learning and whether its influence is cognitive domain-specific (motor vs. language). A sample of 38 young healthy participants was genotyped, screened for background and neuropsychological differences, and tested with two associative implicit learning paradigms in two different cognitive domains, i.e., motor and vocabulary learning. Subjects performed the serial reaction time task (SRTT) to determine implicit motor learning and a recently established associative vocabulary learning task (AVL) for implicit learning of action and object words. To determine the influence of the BDNF polymorphism on domain-specific implicit learning, behavioural i