solvent-free microwave synthesis of aryloxypropanolamines by ring opening of aryloxy epoxides无溶剂微波合成aryloxypropanolamines芳氧基环氧化合物的开环.pdfVIP

Hindawi Publishing Corporation Research Letters in Organic Chemistry Volume 2009, Article ID 109717, 5 pages doi:10.1155/2009/109717 Research Letter Solvent-Free Microwave Synthesis of Aryloxypropanolamines by Ring Opening of Aryloxy Epoxides Rukhsana I. Kureshy,1 Irshad Ahmad,2 Kavita Pathak,1 N. H. Khan,1 Sayed H. R. Abdi,1 H. C. Bajaj,1 and Eringathodi Suresh3 1 Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific and Industrial Research (CSIR), G. B. Marg, Bhavnagar 364 002, Gujarat, India 2 Leibniz-Institute for Surface Modification e.V. (IOM), Permoserstraße 15, 04318 Leipzig, Germany 3 Analytical Science Division, Central Salt and Marine Chemicals Research Institute (CSMCRI), G. B. Marg, Bhavnagar 364 002, Gujarat, India Correspondence should be addressed to Rukhsana I. Kureshy, rukhsana93@yahoo.co.in Received 18 December 2008; Accepted 26 January 2009 Recommended by Kazuaki Ishihara The ring opening reaction of aryloxyepoxides with isopropylamine under solvent-free microwave irradiation produced therapeutically useful β -blockers-aryloxypropanolamines in excellent yield (up to 98%) in 10 minutes which is considerably less than the time taken in classical heating ( ∼16 hours). Copyright © 2009 Rukhsana I. Kureshy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 1. Introduction synthesis of aryloxypropanolamines by ring opening of aryloxyep