schizandrin, an antioxidant lignan from schisandra chinensis, ameliorates aβ1–42-induced memory impairment in mice从五味子对schizandrin,抗氧化剂木酚素,改善aβ1-42-induced小鼠记忆损伤.pdfVIP

Hindawi Publishing Corporation Oxidative Medicine and Cellular Longevity Volume 2012, Article ID 721721, 7 pages doi:10.1155/2012/721721 Research Article Schizandrin, an Antioxidant Lignan from Schisandra chinensis, Ameliorates Aβ 1–42-Induced Memory Impairment in Mice Di Hu,1 Yunfeng Cao,2 Rongrong He,3 Na Han,1 Zhihui Liu,1 Lijing Miao,1 and Jun Yin1 1 Department of Pharmacognosy, Shenyang Pharmaceutical University, Shenyang 110016, China 2 National Population and Family Planning Key Laboratory of Contraceptives Drugs Devices, Shanghai Institute of Planned Parenthood Research, Shanghai 200032, China 3 Pharmacy College, Jinan University, Guangzhou 510632, China Correspondence should be addressed to Jun Yin, yinjun2002@ Received 7 March 2012; Revised 14 May 2012; Accepted 14 May 2012 Academic Editor: David Vauzour Copyright © 2012 Di Hu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In the present study, we examined the effect of schisandrin (SCH) of Schisandra chinensis on the amyloid-beta1–42- (Aβ 1–42-) induced memory impairment in mice and elucidated the possible antioxidative mechanism. Mice were intracerebroventricular (i.c.v.) injected with the aggregated Aβ 1–42 and then treated with SCH (4, 12, and 36 mg/kg body weight) or donepezil (DPZ), a reference drug (0.65 mg/kg) by intragastric infusion for 14 days. Noncognitive disturbances and cognitive performance were evaluated by locomotor activity test, Y-maze test, and water maze test. Antioxidative enzyme activities including superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) and levels of malondialdehyde (MDA),