sparse representation for classification of tumors using gene expression data稀疏表示的分类使用基因表达数据的肿瘤.pdfVIP

Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2009, Article ID 403689, 6 pages doi:10.1155/2009/403689 Research Article Sparse Representation for Classification of Tumors Using Gene Expression Data Xiyi Hang1 and Fang-Xiang Wu2, 3 1 Department of Electrical and Computer Engineering, California State University, Northridge, CA 91330, USA 2 Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada S7N 5A9 3 Divsion of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada S7N 5A9 Correspondence should be addressed to Fang-Xiang Wu, faw341@mail.usask.ca Received 24 November 2008; Accepted 12 January 2009 Recommended by Dechang Chen Personalized drug design requires the classification of cancer patients as accurate as possible. With advances in genome sequencing and microarray technology, a large amount of gene expression data has been and will continuously be produced from various cancerous patients. Such cancer-alerted gene expression data allows us to classify tumors at the genomewide level. However, cancer-alerted gene expression datasets typically have much more number of genes (features) than that of samples (patients), which imposes a challenge for classification of tumors. In this paper, a new method is proposed for cancer diagnosis using gene expression data by casting the classification problem as finding sparse representations of test samples with respect to training samples. The sparse representation is computed by the l1-regularized least square method. To investigate its performance, the proposed method is applied to six tumor gene expression datasets and compared with various support vector machine (SVM) methods. The experimental results have shown th