synthesis and reactions of 3-(2-chloromethyl-carbonylamino)tetrachloroquinazolin-2,4-dione的合成和反应3 -(2-chloromethyl-carbonylamino)tetrachloroquinazolin-2 4-dione.pdfVIP

Hindawi Publishing Corporation Organic Chemistry International Volume 2012, Article ID 284947, 4 pages doi:10.1155/2012/284947 Research Article Synthesis and Reactions of 3-(2-Chloromethyl-carbonylamino) tetrachloroquinazolin-2,4-dione M. A. Hassan,1 A. M. M. Younes,2 M. M. Taha,2 and A. Abdel-Monsef2 1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Industries, Sinai University, Arish, Egypt 2 Chemistry Department, Faculty of Science, South Valley University, Qena 83523, Egypt Correspondence should be addressed to A. Abdel-Monsef, bakooos2004@ Received 16 April 2012; Accepted 4 June 2012 Academic Editor: Cyril Parkanyi Copyright © 2012 M. A. Hassan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. A series of tetrachloroquinazolin-2,4-dione derivatives were synthesized using appropriate synthetic route and characterized by IR, 1H NMR, MS, and elemental analysis. The synthesized compounds were evaluated for their preliminary in vitro antibacterial activity towards Salmonella typhi, Staphylococcus aureus, and Bacillus cereus. 1. Introduction in the present study, 3-(2-chloromethylcarbonylamino)te- trachloroquinazolin-2,4-dione 2, was prepared by the reac- Pyrimidine and quinazoline derivatives have occupied a tion of 3-aminotetrachloroquinazolin-2,4-dione [ 16] 1 with unique position in medicinal chemistry; the pyrimidine ring chloroacetyl chloride. Reaction of the starting compound 2 is present in a large number of biological important com-