tirapazamine-doxorubicin interaction referring to heart oxidative stress and ca2+ balance protein levelstirapazamine-doxorubicin互动指的是心脏氧化应激和ca2 +平衡蛋白质含量.pdfVIP

Hindawi Publishing Corporation Oxidative Medicine and Cellular Longevity Volume 2012, Article ID 890826, 9 pages doi:10.1155/2012/890826 Research Article Tirapazamine-Doxorubicin Interaction Referring to Heart Oxidative Stress and Ca2+ Balance Protein Levels Justyna Sliwinska,1 Jaroslaw Dudka,2 Agnieszka Korga,2 Franciszek Burdan,3 Wlodzimierz Matysiak,4 Barbara Jodlowska-Jedrych,4 Slawomir Mandziuk,5 and Katarzyna Dawidek-Pietryka6 1 Department of Clinical Pathomorphology, Medical University in Lublin, 20-059 Lublin, Poland 2 Medical Biology Unit, Medical University in Lublin, 20-059 Lublin, Poland 3 Department of Human Anatomy, Medical University in Lublin, 20-059 Lublin, Poland 4 Department of Histology and Embryology, Medical University in Lublin, 20-059 Lublin, Poland 5 Department of Pneumology, Oncology and Alergology, Medical University in Lublin, 20-059 Lublin, Poland 6 Lloyds Pharmacy, Meadowhead, Sheffi eld S8 9TU, UK Correspondence should be addressed to Jaroslaw Dudka, ave123@wp.pl Received 8 December 2011; Revised 3 March 2012; Accepted 11 March 2012 Academic Editor: Oren Tirosh Copyright © 2012 Justyna Sliwinska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Doxorubicin (DOX) causes long-term cardiomyopathy that is dependent on oxidative stress and contractility disorders. Tirapazamine (TP), an experimental adjuvant drug, passes the same red-ox transformation as DOX. The aim of the study was to evaluate an effect of tirapazamine on oxidative stress, contractile protein level, and cardiomyocyte necrosis in rats administered