tocotrienol supplementation improves late-phase fracture healing compared to alpha-tocopherol in a rat model of postmenopausal osteoporosis a biomechanical evaluationtocotrienol补充改善晚期骨折愈合与绝经后骨质疏松症的α-生育酚在大鼠模型生物力学评价.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 372878, 7 pages doi:10.1155/2012/372878 Research Article Tocotrienol Supplementation Improves Late-Phase Fracture Healing Compared to Alpha-Tocopherol in a Rat Model of Postmenopausal Osteoporosis: A Biomechanical Evaluation Sharlina Mohamad,1, 2 Ahmad Nazrun Shuid,1 Sabarul Afian Mokhtar,3 Shahrum Abdullah,4 and Ima Nirwana Soelaiman1 1 Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abd Aziz, 50300 Kuala Lumpur, Malaysia 2 Cluster of Integrative Medicine, Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, 13200 Kepala Batas, Pulau Pinang, Malaysia 3 Department of Orthopedics, UKM Medical Centre, Jalan Yaacob Latiff , Bandar Tun Razak, Cheras, 56000 Kuala Lumpur, Malaysia 4 Department of Mechanical and Materials Engineering, Faculty of Engineering, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia Correspondence should be addressed to Ahmad Nazrun Shuid, anazrun@ Received 29 May 2012; Accepted 15 June 2012 Academic Editor: Norazlina Mohamed Copyright © 2012 Sharlina Mohamad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This study investigated the effects of α-tocopherol and palm oil tocotrienol supplementations on bone fracture healing in postmenopausal osteoporosis rats. 32 female Sprague-Dawley rats were divided into four groups. The first group was sham operated (SO), while the others were ovariectomised. After 2 months, the right femo