羧酸化的壳聚糖 和PVA.pdfVIP

Biomacromolecules 2008, 9, 349–354 349 Electrospun Water-Soluble Carboxyethyl Chitosan/Poly(vinyl alcohol) Nanofibrous Membrane as Potential Wound Dressing for Skin Regeneration Yingshan Zhou,† Dongzhi Yang,‡ Xiangmei Chen,§ Qiang Xu,§ Fengmin Lu,§ and Jun Nie*,†,‡ Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan, 430072, P. R. China, State Key Laboratory of Chemical Resource Engineering and College of Material Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, P. R. China, and Department of Microbiology, Peking University Health Science Center, Beijing, 100083, P. R. China Received August 12, 2007; Revised Manuscript Received October 30, 2007 Biocompatible carboxyethyl chitosan/poly(vinyl alcohol) (CECS/PVA) nanofibers were successfully prepared by electrospinning of aqueous CECS/PVA solution. The composite nanofibrous membranes were subjected to detailed analysis by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray diffraction (XRD). SEM images showed that the morphology and diameter of the nanofibers were mainly affected by the weight ratio of CECS/PVA. XRD and DSC demonstrated that there was strong intermolecular hydrogen bonding between the molecules of CECS and PVA. The crystalline microstructure of the electrospun fibers was not well developed. The potential use of the CECS/PVA electrospun fiber mats as scaffolding materials for skin regeneration was evaluated in vitro usin