狼疮肾用药指南（Lupus kidney medication guide）.doc

狼疮肾用药指南（Lupus kidney medication guide） Good doctor continuing medical education center Your location: Home Page my continuing education Secondary glomerulopathy Indications for lupus nephritis China-Japan Friendship Hospital of Ministry of health, Chen Yipu First, commonly used treatment measures (I) basic treatment The so-called basic treatment, that is, once the diagnosis is established, that is, the beginning of the use of treatment measures. In the past, only hormone was used for basic treatment; after 80s, it was advocated that other immune preparations were added on the basis of hormone application. Use of steroid hormones or hormone plus cyclophosphamide and azathioprine, mycophenolate mofetil or cyclosporine A. New drugs, such as leflunomide and tacrolimus, have also been reported for lupus nephritis, but their legal indications do not include lupus and kidney disease. (two) intensive treatment Intensive care is needed in some critically ill patients. Methylprednisolone, cyclophosphamide, plasma exchange and plasma adsorption are all the fields of intensive treatment. (three) other treatments If necessary, large doses of IgG or anti CD4 monoclonal antibodies may be administered intravenously to correct immune abnormalities in lupus nephritis. Two. Indications for lupus nephritis At present, there are many treatments for lupus nephritis, but how to treat them rationally is still an important topic. The indication of lupus nephritis should be mastered correctly in the treatment. (I) indications for basic treatment; 1, hormone combined with cyclophosphamide or azathioprine Hormone combined with cyclophosphamide is the most widely used basal treatment at present. Cyclophosphamide began to use in 70s and is now the most widely used cytotoxic drug. Application of high dose cyclophosphamide rheumatism, but western countries believe that the application does not require too much to accumulated a certain amount of cyclophosphamide, such as renal control in 8g ~ 12g;