疯牛病1（Mad cow disease 1）.docVIP

疯牛病1（Mad cow disease 1） Research progress of mad cow disease Since late 1980s the first large-scale outbreaks of mad cow disease since then, in a number of countries also have a case of mad cow disease, mad cow disease seriously affects the development of the international trade, and a serious threat to human life and health. To analyze the clinical characteristics, etiology and pathogenesis of BSE, and to provide reference for the prevention and treatment of mad cow disease. Keywords BSE; etiology; pathogenesis; Mad cow disease (BSE) is a transmissible spongiform encephalopathy (Transmissible spongiform, encephalopathies, TSE) from normal prion protein (PrPC) is a heterogeneous abnormal prion protein (PrPSC) is a fatal neurodegenerative disease caused by the occurrence in some mammals. Scrapie (SC) is a prion disease, first were known, after people have been found in animal like Niu Haimian encephalopathy (BSE) (BSE), infectious mink disease (TME), chronic wasting disease of hybrid deer and moose (CWD) and feline spongiform encephalopathy (FSE). Human prion diseases have been found in Creutzfeldt Jakob disease (CJD) and Creutzfeldt Jakob disease (NCJD), kuru (Kuru-Disease) and Gerstman syndrome (GSS) and fatal familial insomnia (FFI). 1 the history of mad cow disease Animal spongiform encephalopathy has long been documented. In the eighteenth Century, scrapie in sheep (Scrapie) was observed in europe. Mad cow disease first broke out in Britain in 1986. According to OIE official statistics, by September 2008, the British confirmed BSE disease cattle reached 184575, in 1993 reached the highest peak [1]. Although the pathogenesis of BSE has not yet been fully understood, it is generally believed that bovine consumption of meat and bone meal feeds on sheeps scrapie virus and causes mad cow disease. With the cessation of meat and bone meal in the aquaculture industry, the number of outbreaks is on the decline every year. As many countries, especially European Union coun