肾病综合征如何治疗（How is nephrotic syndrome treated）.docVIP

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2017-09-02 发布于河南
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肾病综合征如何治疗（How is nephrotic syndrome treated）.doc

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肾病综合征如何治疗（How is nephrotic syndrome treated）

肾病综合征如何治疗（How is nephrotic syndrome treated） (1) treatment of primary diseases that cause nephrotic syndrome 1. glucocorticoid treatment of renal disease is mainly anti-inflammatory effect of glucocorticoids. It can relieve acute inflammation exudation, lysosomal membrane stability, reduce the deposition of fibrin, reduce capillary permeability and reduce urinary protein leakage; in addition, can inhibit the proliferative response in chronic inflammation, reduce fibroblast activity, reduce tissue repair and fibrosis. The response of glucocorticoids to nephrotic syndrome depends greatly on its pathological type and is generally believed to be the most promising for minimal change nephropathy. The hormone preparation has short acting (half-life 6 ~ 12 hours): prednisone (20mg); the effect of (12 to 36 hours): prednisone (5mg), P Nixonn Ron (5mg), Kap Nixonn Ron (4mg), f-oh P Nixonn Ron (4mg); long term (48 ~ 72 hours: dexamethasone (0.75mg)), Batamison (0.60mg). The hormone can be absorbed rapidly through the gastrointestinal tract, so the tablet is the most commonly used dosage form. The first dose was usually prednisone 1mg/ (kg * d), and children ranged from 1.5 to 2mg/ (kg * D). After 8 weeks of treatment, the effective application should be maintained, then gradually reduced, generally every 1 to 2 weeks Jianyuan dose of 10% ~ 20%, the less dose decreasing less, slower. The maintenance and maintenance time of the hormone varied depending on the case, and the minimum dose used for the absence of clinical symptoms was lower than 15mg/d. At the maintenance stage, hormonal changes are adjusted for weight changes, infections, surgery, and pregnancy. After 8 weeks or more regular treatment failed, the factors that affect the curative effect should be excluded, such as weight gain and renal vein thrombosis caused by infection, edema, and so on, should be diagnosed and treated as soon as possible. The oral steroid treatment of adverse reactions, severe edema effect on th