谷氨酸脱羧酶抗体和胰岛细胞抗体联合检测对1型糖尿病早期诊断的意义（The significance of combined detection of glutamic acid decarboxylase antibody and islet cell antibody in the early diagnosis of type 1 diabetes mellitus）.docVIP

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谷氨酸脱羧酶抗体和胰岛细胞抗体联合检测对1型糖尿病早期诊断的意义（The significance of combined detection of glutamic acid decarboxylase antibody and islet cell antibody in the early diagnosis of type 1 diabetes mellitus）.doc

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谷氨酸脱羧酶抗体和胰岛细胞抗体联合检测对1型糖尿病早期诊断的意义（The significance of combined detection of glutamic acid decarboxylase antibody and islet cell antibody in the early diagnosis of type 1 diabetes mellitus） The significance of combined detection of glutamic acid decarboxylase antibody and islet cell antibody in the early diagnosis of type 1 diabetes mellitus 2011-01-16 Dong Weiping, Zhang Hongde, Hu Yuanfeng, Zhang Aifang, Wang Lijuan, Wang Yufei [Abstract] objective to islet cell antibody in 984 cases of patients with diabetes mellitus (ICA), glutamic acid decarboxylase antibody (GADA) and serum C peptide were detected and analyzed, and the positive rate of GADA and ICA in patients with positive islet function, in order to clear ICA and GADA detection in the diagnosis of type 1 diabetes early significance. Methods ICA was detected by immunohistochemistry, GADA was detected by ELISA, and fasting and postprandial C peptide were detected by radioimmunoassay. Results ICA and / or GADA positive (positive group) 168 cases (17%) were higher than ICA positive rate (10.5%) and GADA positive rate (12%, P 0.05). The positive rate of GADA in adult patients (10.5%) was higher than that in ICA (7.7%, P 0.05), and the positive rate of ICA in adolescents (46.5%) was higher than that in GADA (31%, P 0.01). Fasting and postprandial C peptide [(325 + 368) pmol/L and (745 + 767) pmol/L] in antibody positive patients were significantly lower than those in antibody negative patients [(701 + 434) pmol/L and (1614 + 967) pmol/L, P 0.001]. Conclusion the islet function of autoantibody positive patients is lower than that of negative patients, which suggests that the islet function of the patients with positive autoantibodies is obviously impaired. In adults with diabetes, GADA detection is more important than ICA, while in adolescents with diabetes, ICA is higher than GADA. The positive results of the two antibodies are often inconsistent. Combined detection can improve the sensitivity of diagnosis, and