阿莫西林说明书（Amoxicillin manual）.doc

阿莫西林说明书（Amoxicillin manual） Amoxicillin Capsules Name used before English name AMOXICILLIN CAPSULES Pinyin name AMOXILING JIAONANG Drug category penicillins The product is capsule. Pharmacology and toxicology of amoxicillin for penicillin antibiotics against Streptococcus pneumoniae, hemolytic streptococcus, Streptococcus, penicillinase Staphylococcus, Enterococcus faecalis and other gram positive cocci, Escherichia coli, proteus, Salmonella, Haemophilus influenzae, Neisseria gonorrhoeae and other gram negative bacteria dont produce beta lactamase strains and Helicobacter pylori has good antibacterial activity. Amoxicillin acts as a bactericidal agent by inhibiting the synthesis of bacterial cell walls, causing the bacteria to rapidly become spheroids and dissolved and ruptured. After oral administration, the absorption of this product is rapid, about 75% ~ 90% can be absorbed from the stomach and intestines, and the influence of food on the absorption of drugs is not significant. After oral administration of 0.25 g and 0.5g, the peak concentration of serum (Cmax) was 3.5 to 5.0mg/L and 5.5 to 7.5mg/L, respectively, and the peak time was 1~2 hours. This product is well distributed in most tissues and fluids. The average drug concentrations in sputum of patients with acute exacerbation of pneumonia or chronic bronchitis were 2~3 and 6 hours after oral administration of 0.5g, respectively, while 0.52mg/L and 0.53mg/L were 11mg/L and 3.5mg/L at the same time. In children with chronic otitis media, the concentration of 6.2mg/L in the middle ear fluid was 1~2 hours after oral administration of 1G. After 2 hours of oral administration of 1g, the concentration of CSF in CSF of tuberculous meningitis patients is 0.1 ~ 1.5mg/L, which is equivalent to 0.9% to 21.1% of the serum concentration during the same period. This product can pass the placenta, in umbilical cord blood concentration of maternal plasma concentration of 1/4 ~ 1/3, in milk, sweat and tears are also included