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Ascites,Peritoneal cavity,Peritoneal fluid,Etiology of ascites 腹水,腹膜腔,腹水,腹水的病因
Type 1 HRS: Doubling of initial serum creatinine level to 205mg/dl or a 50% cause decreasing in 24-hour creatinine clearance to 20ml/min in 2 weeks. Mortality is 90% without liver transplantation. Type 2 HRS: RF has a slower progressive course. Occur in the setting of chronic or acute liver disease with portal hypertension. Low GFR (with creatinine 1.5mg/dl) No evidence of shock, bacterial infection, or treatment with nephrotoxic agents + absence of GI fluid losses or renal fluid losses. No improvement in renal function following diuretic withdrawal. Proteinuria 500mg/dl and no US evidence of renal disease or obstructive uropathy. Treatment of hepatorenal syndrome: Supportive Liver transplantation: Tx of Choice. It corrects both liver and kidney disease. Is associated with up to 60% survival rate in 3 years. Shortage of donor organs leads to a high rate of death in these patients. Complications of Ascites 3- Spontaneous Bacterial Peritonits 20% of patients with cirrhotic ascites Diagnosed with neutrophil count of 250/mm3 Gram – neg organisms in 60% of cases (E.coli and Klebsiella pneumoniae ) Gram + organisms 25% of cases (Strep species ) Symptoms: Abdominal pain, fever, development of hepatic encephalopathy, diarrhea, hypothermia and shock. Ascitic Protein level1 g/dl is a risk for Spontaneous Bacterial Peritonits. Treatment: Cefotaxime sodium References Scincedirect Uptodate eMedicine Health MedicineN Family Practice N Thank you Serum-Ascites Albumin Gradient Best single test for classifying ascites into portal hypertensive and non-portal hypertensive causes. Calculated by: Serum albumin – Ascites albumin= SAAG SAAG 1.1 g/dL= Portal HTN SAAG 1.1 g/dL= Non-Portal hypertensive cause SAAG SAAG 1.1 Liver Disease Hepatic Congestion CHF Tricuspid Insufficiency Massive Hepatic Metastasis SAAG 1.1 Peritoneal carcinomatosis Peritoneal Infection (TB, Fungal, CMV) Nephrotic syndrome Pancreatic ascites Total protein: Helpful in diagnosing spontane
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