about three-negative breast cancer（对三种乳腺癌）.docVIP

About three-negative breast cancer Breast cancer is the most common malignancy of women, its incidence has increased year by year and dropping, according to World Health Organization, the International Cancer Research Center The latest statistics show that worldwide there are about 1.2 million breast cancer patients each year, of which 540,000 of new cases, about 50 million people each year die of the disease. Cancer Research Office of China’s research data shows that in 2005 women with breast cancer incidence rate of 24.5/10 our million, ranking first in various types of cancer, 2000-2005, the incidence of breast cancer increased by 38.5%. Experts predict that 20 years after breast cancer will be the highest incidence of malignant tumors in China [1]. Breast cancer is a highly heterogeneous tumor characteristics in terms of molecular biology, morphology, immunophenotype or response to treatment, both the existence of significant differences, to understand these differences can be more individualized and effective treatment [2]. At present the combination of immune and gene expression of different products, divided into five subtypes of breast cancer, hormone receptor-positive classes, respectively luminalA type and luminalB type of tumor cell gene expression and from the inner tube luminal epithelial cells similar; HER2 over-expressing normal mammary gland gene expression type (normal-like, with high expression of basal epithelial cell gene expression of luminal epithelial cells, while genes characteristic of basal cell-like type, and normal breast epithelial cells express similar basal [ 3]. Triple-negative breast cancer (TNBC was only raised in recent years, and is the estrogen receptor (ER, progesterone receptor (PR and human epidermal growth factor receptor 2 subtype (HER2-negative breast cancer are, Breast cancer accounts for about 12% -40% occur in women 40 years of age, a higher prevalence in African Americans, has a special biological behav