analysis of geranium leaves the heart through the soft capsule on long-term toxicity in rats（天竺葵叶心通过分析软胶囊对大鼠的长期毒性）.docVIP

Analysis of Geranium leaves the heart through the soft capsule on long-term toxicity in rats [Abstract] Objective: To observe orientin soft capsule leaves the heart through the long-term toxicity in rats Methods: 160 SD rats were randomly divided into high, medium and low-dose group and control group, male and female, fed daily 1 , continuous administration of 26 weeks, the general condition of rats, body weight, food intake and administration of 13,26-week and 4 weeks after withdrawal of rats hematology, blood chemistry, coagulation, organ coefficient, anatomy and histopathological changes in the situation. Results: Geranium leaves the heart through the soft capsule high dose group female rats administered 13 weeks of total bilirubin (TBIL), administered 26 weeks creatinine (CREA) and TBIL, administration of 26 weeks coagulation ester of the original time (PT) and the high dose group male rats administered 26 weeks Cl-concentration with a slight difference between the control group, stopping 4 weeks after return to normal, no abnormal histopathology rest of the indicators and each dose group control group, there was no significant difference Conclusion: Geranium leaves the heart through the soft capsule in the clinical dose range of toxicity, the use of safety. [Keywords] toxicity test; red Polygonum; rat, Sprague-Dawley; orientin leaves the heart through the soft capsule; long-term toxicity [Abstract] Objective: To study the long-term toxicity of Hongyexintong soft capsules to rats.Methods: One hundred and sixty SD rats were randomly divided into four groups (40 in each group), and orally given the medicine with doses of 50, 25, or 12.5 g / kg of crude drug, or with bean oil of 0.5% CMC-Na (for control group) daily for 26 weeks.The physical status (body weight, growth rate and appetite), hematological parameters, blood biochemistry, blood cotting, organ index, and tissue pathological changes of rats were checked in the 13th week, and 26th week of the a