不同剂量坦索罗辛在输尿管下段结石中的疗效比较.docVIP

不同剂量坦索罗辛在输尿管下段结石中的疗效比较 马志远 王阳 辛航 乔保平 (郑州大学第一附属医院泌尿外科 中国河南郑州 450052 ) （备注：马志远为第一作者，王阳为第二作者，辛航为第三作者，乔保平为通讯作者；作者单位均为郑州大学第一附属医院泌尿外科；通讯作者乔保平为教授，主任医师，博士生导师，联系电话0371邮箱zhangyaling@；第一作者马志远为硕士研究生，研究方向为泌尿系疾病的基础与临床，联系电邮箱mzhy1130@） [摘要]　 目的 　比较不同剂量坦索罗辛在治疗输尿管下段结石中的疗效。 方法 　60例输尿管下段结石患者随机分为两个组，各30例。组Ⅰ：给予坦索罗辛0.2mg，1次/d；组Ⅱ：给予坦索罗辛0.4mg，1次/d；观察随访2周。 结果 组Ⅰ和组Ⅱ结石完全排出率分别为16例（53%）和24例（80%）, 两个组相互比较有统计学意义 ( P0.05)；平均排石时间组Ⅰ和组Ⅱ分别为（7.2±2.6d）、（5.5±2.3d），两个组比较有统计学意义 ( P0.05)；2周内因发生肾绞痛而需镇痛治疗者分别为11例（37%）和4例（13%），两个组比较有统计学意义 (P0.05)；2周内两组均未出现明显不良反应，无因不良反应而退出者。 结论 　 坦索罗辛能有效促进输尿管下段结石排出,缩短排石时间,并减少排石过程中肾绞痛发生；在结石排出率、排出时间、降低肾绞痛发生率上用坦索罗辛0.4mg/d明显优于用坦索罗辛0.2mg/d。 [关键词] 坦索罗辛;输尿管结石;剂量。 Comparison of clinical effects of different dose of tamsulosin on patients with lower ureteral stones Ma Zhiyuan, Wang Yang, Xin Hang, Qiao Baoping (Department of Urology, the First Affiliated Hospital Of Zhengzhou University Zhengzhou Henan China 45052) [Abstract]: Objective　To compare the clinical effects of different dose of tamsulosin on patients with lower ureteral stones. Methods Sixty patients with lower ureteral stones were randomly divided in to 2 groups(30 cases in each group).GroupⅠreceived tamsulosin(0.2mg,once daily),while GroupⅡreceived tamsulosin(0.4mg,once daily). All patients were observed for 2 weeks. Results During 2 weeks, expulsion of stones was observed in 16 cases(53%) of groupⅠ and 24 cases(80%) of groupⅡ,The difference in expulsion rates between two groups was statistically significant (P0.05). The mean expulsion time of the two groups was (7.2±2.6d) and (5.5±2.3d), the difference in mean expulsion time between two groups was statistically significant (P0.05). The renal colic was observed in 11 cases(37%) of groupⅠ and 4cases(13%) of groupⅡ within 2 weeks, with significant different between the two groups(P0.05). No obvious adverse reactions occurred and no one withdrew from therapy because of adverse reactions during the 2 weeks. Conclusion Tamsulosin is effective for