内毒素的去除.pdf

第 30 卷 　第 5 期 卫 　生 　研 　究 Vol. 30 　No. 5 2001 年 　9 月 JOURNAL OF HYGIENE RESEARCH Sep. 　2001 　315 ( ) 文章编号 2001 ·实验技术· 超滤法去除细菌内毒素 王 　铮 　张惠新 　戴海平 天津工业大学膜科学与技术研究所 ,天津　300160 摘要 : 利用聚砜为膜材料 ,通过相转化法制成外压式聚砜中空纤维超滤膜 ,制成的中空纤维超滤器 (φ ) 90mm ×500mm ,水通量大于 150 Lh ·atm ,截留分子量在 6000 左右 ,可去除细菌内毒素 ,达到药典规定的指 标。文中介绍了热原本质、定量表示及测定方法 ;介绍了外压式中空纤维超滤装置在药液除热原工艺中的使 用情况 ,并提出在运用时应注意的问题。 关键词 :细菌内毒素 　中空纤维 　超滤装置 中图分类号:R19739 　　　　　　文献标识码 :B Study on the elimination of bacterial endotoxins by ultrafiltration device Wang Zheng ,Zhang Huixin ,Dai Haiping Membrane SCI TECH INST of Tianjin Polytechnic University , Tianjin　300160 ,China Abstract :An externalpressed polysulfone hollow fiber UF membrane , was made by phase inversion method. The cut (φ ) off molecular weight was 6000. The water permeation rate of this membrane module 90 ×500mm is more than 150 L hr. atm. The operating results show that the elimination of bacterial endotoxins by this membrane has reached the national standard in pharmacopoeia , and this technology is worthy to be extended over to medical industry. In addition , the essence of pyreotogen , the quantification units and measure methods for pyreotogen , and the operating conditions of UF device in the process of eliminating pyreotogen are introduced. Some critical points in operation was discussed. Key words :bacterial endotoxins , hollow fiber ,