卡培他滨间断用药治疗合并有多种慢性疾病老年性晚期乳腺癌临床疗效研究.docVIP

卡培他滨间断用药治疗合并有多种慢性疾病老年性晚期乳腺癌临床疗效研究[摘要] 目的：观察卡培他滨间断用药治疗合并有多种慢性疾病的老年性乳腺癌患者的疗效及副作用。方法：26例晚期老年性乳腺癌患者，应用单药卡培他滨间断化疗。卡培他滨每日2 500 mg/m2，d1～14。中位化疗间隔时间为2.5个月，中位化疗周期为5个周期。结果：CR 0例（0），PR 3例（11.6%），SD 18例（69.2%），PD 5例（19.2%），1年存活率为92.3%，2年存活率为88.5%，3年存活率达76.9%。不良反应轻，主要为白细胞减少和胃肠道反应。对血糖、血压、心功能无明显影响。结论：对于合并有多种慢性疾病的老年性晚期乳腺癌，单药卡培他滨间断治疗是值得选择和进一步研究的治疗方案。 [关键词] 卡培他滨；间断化疗；老年性晚期乳腺癌；疗效分析 [中图分类号] R737.9 [文献标识码] A [文章编号] 1674-4721（2012）01（b）-053-02 Clinical effect analysis of capecitabine intermittent therapy for the treatment of advanced breast carcinoma of old women associated with various chronic diseases GAO Jinsuo The Third People’s Hospital of Hefei City in Anhui Province, Hefei 230022, China [Abstract] Objective: To evaluate the efficacy and safety of capecitabine intermittent therapy for the old women with advanced breast carcinoma associated with various chronic diseases. Methods: Total 26 patients were treated with 2 500 mg/m2 of capecitabine d1-14. The median interval between chemotherapy were 2.5 months, median chemotherapy cycle were 5 cycles. Results: Complete remission was 0 case (0), the partial response were 3 cases (11.6%), stable disease were 18 cases (69.2%), progressive diesease were 5 cases (19.2%). 1-year survival rate was 92.3%, 2-year survival rate was 88.5%, 3-year survival rate was 76.9%. The mainly adverse effects included leucopenia, gastrointestinal reactions. There was no significant effect on blood glucose, blood pressure and heart function. Conclusion: To the old women with advanced breast carcinoma associated with various chronic diseases, capecitabine intermittent therapy is worthy of further study and treatment options. [Key words] Capecitabine; Intermittent therapy; Old women with metastatic breast carcinoma; Effect analysis 乳腺癌是女性最常见的恶性肿瘤之一，我国乳腺癌在城市中的发病率为女性恶性肿瘤的第二位，农村中为第五位。乳腺癌已经成为妇女健康的最大威胁。随着我国人口老年化趋势，老年人乳腺癌的发病率明显增加。老年乳腺癌的患者多合并多种慢性疾病，身体各器官功能减低，特别是合并高血压、糖尿病、冠心病老年性乳腺癌患者，经过手术治疗，化疗以及内分泌等治疗，出现再转移现象，目前采取何种治疗还没有相关的报道。笔者采用单药卡培他滨间断治疗老年性晚期乳