a new sesquiterpene from the fruits of daucus carota l.一个新的水果的倍半萜烯胡萝卜胡萝卜l。.pdfVIP

Molecules 2009, 14, 2862-2867; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article A New Sesquiterpene from the Fruits of Daucus carota L. Hong-Wei Fu, Lin Zhang, Tao Yi and Jing-Kui Tian * Zhejiang Provincial Key Laboratory for Chinese Medicine Screening, Exploitation Medicinal Effectiveness Appraisc for Cardio-cerebral, Vascular Nervous System, The Key Laboratory of Biomedical Engineering Ministry of Education, China; Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China; E-mail: zxxtjk@ (H.W.F.) * Author to whom correspondence should be addressed; E-mail: tjk@; Tel.: +86-571 Fax: +86-571 Received: 6 July 2009; in revised form: 27 July 2009 / Accepted: 29 July 2009 / Published: 3 August 2009 Abstract: Phytochemical investigation of the fruits of Daucus carota L. resulted in the isolation of a new sesquiterpene named as daucucarotol (1). Its structure was elucidated on the basis of 1D and 2D NMR experiments, coupled with MS studies. To our knowledge, compound 1 is the first example for a natural eudesmane sesquiterpene with a hydroxymethyl group located at a methine carbon rather than a usual quaternary carbon in the two fused six-membered ring systems. Keywords: Daucus carot ; umbelliferae; sesquiterpene Introduction Daucus carota L. (Umbelliferae) is a biennial herb, which is widely distributed throughout the World. The fruits of the plant (common