a new triterpenoid saponin from abrus precatorius linn的新三萜皂苷abrus precatorius绝壁.pdfVIP

Molecules 2012, 17, 295-302; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article A New Triterpenoid Saponin from Abrus precatorius Linn Zhi-Hui Xiao 1,2, Fa-Zuo Wang 1, Ai-Jun Sun 1, Chuan-Rong Li 1, Cai-Guo Huang 3 and Si Zhang 1,* 1 Key Laboratory of Marine Bio-Resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China; E-Mails: xzh_77@ (Z.-H.X.); wangfazuo@ (F.-Z.W.); sunaj@ (A.-J.S.); llchuanr@163.com (C.-R.L.) 2 Graduate University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China 3 Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China; E-Mal: huangcaig@ * Author to whom correspondence should be addressed; E-Mail: zhsimd@; Tel.: +86-020-8445-3103; Fax: +86-020-8902-1672. Received: 30 November 2011; in revised form: 20 December 2011 / Accepted: 23 December 2011 / Published: 30 December 2011 Abstract: A new triterpenoid saponin, 3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl subprogenin D (1), together with six known triterpenoids: subprogenin D (2), abrusgenic acid (3), triptotriterpenic acid B (4), abruslactone A (5), abrusogenin (6) and abrusoside C (7) were isolated from the leaves and stems of Abrus precatorius . Their structures were elucidated on the basis of physical and NMR analysis, respectively. Compounds 5 and 6 showed moderate cytotoxicity ag