a novel active targeting preparation, vinorelbine tartrate (vlbt) encapsulated by folate-conjugated bovine serum albumin (bsa) nanoparticles preparation, characterization and in vitro release study英文论文.pdfVIP

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a novel active targeting preparation, vinorelbine tartrate (vlbt) encapsulated by folate-conjugated bovine serum albumin (bsa) nanoparticles preparation, characterization and in vitro release study英文论文.pdf

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a novel active targeting preparation, vinorelbine tartrate (vlbt) encapsulated by folate-conjugated bovine serum albumin (bsa) nanoparticles preparation, characterization and in vitro release study英文论文

Materials 2012, 5, 2403-2422; doi:10.3390/ma5112403 OPEN ACCESS materials ISSN 1996-1944 /journal/materials Article A Novel Active Targeting Preparation, Vinorelbine Tartrate (VLBT) Encapsulated by Folate-Conjugated Bovine Serum Albumin (BSA) Nanoparticles: Preparation, Characterization and in Vitro Release Study Yong Li, Xiuhua Zhao, Yuangang Zu *, Xue Han, Yunlong Ge, Weiguo Wang and Xinyang Yu Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Harbin 150040, China; E-Mails: liyon (Y.L.); xiuhuazhao@ (X.Z.); amek126.com (X.H.); wo-geyunlong@163.com (Y.G.); wang901234@163.com (W.W.); yuxinyangsarah@163.com (X.Y.) * Author to whom correspondence should be addressed; E-Mail: zygorl@; Tel.: +86-451 Fax: +86-451 Received: 14 September 2012; in revised form: 5 November 2012 / Accepted: 14 November 2012 / Published: 20 November 2012 Abstract: Vinorelbine tartrate (VLBT), as a kind of high hydrophilic and temperature-induced degradation drug, was prepared into nanoparticles by a desolvation procedure. Bovine serum albumin (BSA), as a drug carrier, was stabilized by chemical cross-linking with glutaraldehyde. Firstly, the optimization process of preparing VLBT-loaded BSA nanoparticles (VLBT-BSANPs) was accomplished using response surface methodology (RSM) by desolvation. Then VLBT-BSANPs were conjugated with folate, namely Fa-BSANPs-VLBT. Hence targeting drug carrier delivery