a monoclonal antibody against kininogen reduces inflammation in the hla-b27 transgenic rat反激肽原单克隆抗体减少炎症hla-b27转基因老鼠.pdfVIP

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a monoclonal antibody against kininogen reduces inflammation in the hla-b27 transgenic rat反激肽原单克隆抗体减少炎症hla-b27转基因老鼠.pdf

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a monoclonal antibody against kininogen reduces inflammation in the hla-b27 transgenic rat反激肽原单克隆抗体减少炎症hla-b27转基因老鼠

Available online /content/7/4/R769 Vol 7 No 4 Open Access Research article A monoclonal antibody against kininogen reduces inflammation in the HLA-B27 transgenic rat 1 2 2 2 1 James C Keith Jr , Irma M Sainz , Irma Isordia-Salas , Robin A Pixley , Yelena Leathurby , Leo M Albert1 and Robert W Colman2 1Department of Cardiovascular and Metabolic Diseases Research, Wyeth Research, Cambridge, Massachusetts, USA 2The Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, Pennsylania, USA Corresponding author: Robert W Colman, colmanr@ Received: 31 Jan 2005 Accepted: 3 Mar 2005 Published: 4 Apr 2005 Arthritis Research Therapy 2005, 7:R769-R776 (DOI 10.1186/ar1728) This article is online at: /content/7/4/R769 © 2005 Keith et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract The human leukocyte antigen B27 (HLA-B27) transgenic rat is signs of arthritis (tarsal joint swelling and erythema) were scored a model of human inflammatory bowel disease, rheumatoid daily. The animals were killed and the histology sections were arthritis and psoriasis. Studies of chronic inflammation in other assigned a numerical score for colonic inflammation, synovitis, rat models have demonstrated activation of the kallikrein–kinin and cartilage damage. Administration of monoclonal