a phylogenetic generalized hidden markov model for predicting alternatively spliced exons系统广义隐马尔科夫模型预测或者拼接外显子.pdfVIP

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a phylogenetic generalized hidden markov model for predicting alternatively spliced exons系统广义隐马尔科夫模型预测或者拼接外显子.pdf

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a phylogenetic generalized hidden markov model for predicting alternatively spliced exons系统广义隐马尔科夫模型预测或者拼接外显子

Algorithms for Molecular Biology BioMed Central Research Open Access A phylogenetic generalized hidden Markov model for predicting alternatively spliced exons Jonathan E Allen*1,2 and Steven L Salzberg 1,3 Address: 1Center for Bioinformatics and Computational Biology, University of Maryland Institute for Advanced Computer Studies, University of Maryland, College Park, MD 20742, USA, 2Department of Computer Science, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA and 3Department of Computer Science, University of Maryland, College Park, MD 20742, USA Email: Jonathan E Allen* - jeallen@; Steven L Salzberg - salzberg@ * Corresponding author Published: 25 August 2006 Received: 24 April 2006 Accepted: 25 August 2006 Algorithms for Molecular Biology 2006, 1:14 doi:10.1186/1748-7188-1-14 This article is available from: /content/1/1/14 © 2006 Allen and Salzberg; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: An important challenge in eukaryotic gene prediction is accurate identification of alternatively spliced exons. Functional transcripts can go undetected in gene expression studies when alternative splicing only occurs under specific biological conditions. Non-expression based computational methods support identification of rarely expressed transcripts. Results: A non-expression based statistical method is presented to annotate alterna