a new diterpene glycoside from stevia rebaudiana一个新的从甜叶菊rebaudiana二萜糖苷.pdfVIP

Molecules 2011, 16, 2937-2943; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article A New Diterpene Glycoside from Stevia rebaudiana Venkata Sai Prakash Chaturvedula * and Indra Prakash The Coca-Cola Company, Organic Chemistry Department, Research and Technology, One Coca-Cola Plaza, Atlanta, GA 30313, USA * Author to whom correspondence should be addressed; E-Mail: vchaturvedula@; Tel.: +1-404-676-9257; Fax: +1-404-598-9257. Received: 18 February 2011; in revised form: 29 March 2011 / Accepted: 1 April 2011 / Published: 4 April 2011 Abstract: From the commercial extract of the leaves of Stevia rebaudiana, a new diterpene glycoside was isolated besides the known steviol glycosides including stevioside, rebaudiosides A-F, rubusoside and dulcoside A. The new compound was identified as 13- [(2-O-β-D-glucopyranosyl-3-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy] ent-kaur-16- en-19-oic acid-(2-O--L-rhamnopyranosyl-β-D-glucopyranosyl) ester (1) on the basis of extensive spectroscopic (NMR and MS) and chemical studies. Keywords: Stevia rebaudiana; Compositae; Asteraceae; diterpenoid glycosides; spectral data 1. Introduction Stevia rebaudiana (Bertoni) Bertoni is a perennial shrub of the Asteraceae (Compositae) family native to Brazil and Paraguay, which is often referred to as “the sweet herb of Paraguay”. The major constituents in the leaves of S. rebaudiana are the potently sweet dit