原创力文档a metagenomic study of diet-dependent interaction between gut microbiota and host in infants reveals differences in immune response的宏基因组研究diet-dependent婴儿肠道微生物群与宿主相互作用揭示了免疫应答的差异.pdfVIP
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a metagenomic study of diet-dependent interaction between gut microbiota and host in infants reveals differences in immune response的宏基因组研究diet-dependent婴儿肠道微生物群与宿主相互作用揭示了免疫应答的差异
Schwartz et al. Genome Biology 2012, 13:r32
/2012/13/4/r32
RESEARCH Open Access
A metagenomic study of diet-dependent
interaction between gut microbiota and host in
infants reveals differences in immune response
1,2 3,9 4,5 1,4 4 2
Scott Schwartz , Iddo Friedberg , Ivan V Ivanov , Laurie A Davidson , Jennifer S Goldsby , David B Dahl ,
6 7 7 1,3,8*
Damir Herman , Mei Wang , Sharon M Donovan and Robert S Chapkin
Abstract
Background: Gut microbiota and the host exist in a mutualistic relationship, with the functional composition of
the microbiota strongly affecting the health and well-being of the host. Thus, it is important to develop a synthetic
approach to study the host transcriptome and the microbiome simultaneously. Early microbial colonization in
infants is critically important for directing neonatal intestinal and immune development, and is especially attractive
for studying the development of human-commensal interactions. Here we report the results from a simultaneous
study of the gut microbiome and host epithelial transcriptome of three-month-old exclusively breast- and formula-
fed infants.
Results: Variation in both host mRNA expression and the microbiome phylogenetic and functional profiles was
observed between breast- and formula-fed infants. To examine the interdependent relationship between host
epithelial cell gene expression and bacterial metagenomic-based profiles, the host transcriptome and functionally
profiled microbiome data were subjected to novel multivariate statistical analyses. Gut microbiota metagenome
virulence characteristics concurrently
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