a further contribution to the study of sagittamide a synthesis of a pivotal intermediate belonging to a rare l-series进一步研究贡献sagittamide关键中间体的合成属于一种罕见的l系列.pdfVIP

下载本文档

2
0
约5万字
约 13页
2017-09-05 发布于上海
举报
版权申诉

a further contribution to the study of sagittamide a synthesis of a pivotal intermediate belonging to a rare l-series进一步研究贡献sagittamide关键中间体的合成属于一种罕见的l系列.pdf

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

a further contribution to the study of sagittamide a synthesis of a pivotal intermediate belonging to a rare l-series进一步研究贡献sagittamide关键中间体的合成属于一种罕见的l系列

Molecules 2012, 17, 7709-7721; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article A Further Contribution to the Study of Sagittamide A: Synthesis of a Pivotal Intermediate Belonging to a Rare L-Series Anne Humbert, Karen Plé, Dominique Harakat, Agathe Martinez and Arnaud Haudrechy * Institut de Chimie Moléculaire de Reims, UMR CNRS 7312, Université de Reims, BP 1039, F-51687 REIMS Cedex, France; E-Mails: anne.bak@hotmail.fr (A.H.); karen.ple@univ-reims.fr (K.P.); dominique.harakat@univ-reims.fr (D.H.); agathe.martinez@univ-reims.fr (A.M.) * Author to whom correspondence should be addressed; E-Mail: arnaud.haudrechy@univ-reims.fr; Tel.: +33-2691-3236; Fax: +33-2691-3166. Received: 3 May 2012; in revised form: 13 June 2012 / Accepted: 18 June 2012 / Published: 25 June 2012 Abstract: A key saggitamide intermediate corresponding to a rare sugar framework has been obtained. This approach should help to establish the overall configuration of more complex structures of the sagittamide family. Keywords: sagittamide; L-altrose; L-talose; epoxide opening; asymmetric dihydroxylation 1. Introduction Sagittamides A–F (1–6, Figure 1) are unprecedented marine natural products isolated from an unidentified tropical didemnid tunicate collected in Micronesia and described by Molinski [1,2]. These compounds are characterized by an -dicarboxylic acid (C-26 or C-28) that is acylated at each terminus by a different amino acid (L-ornithine o