a proteomic style approach to characterize a grass mix product reveals potential immunotherapeutic benefit蛋白质组学风格的方法描述一个草混合产品显示潜在的免疫治疗的好处.pdfVIP

ORIGINAL ARTICLE A Proteomic Style Approach To Characterize a Grass Mix Product Reveals Potential Immunotherapeutic Benefit Alan Bullimore, BSc, Nicola Swan, MSc, Wemimo Alawode, PhD, and Murray Skinner, PhD leukotri-enes,2,3 which cause early symptoms such as rhi- Background: Grass allergy immunotherapies often consist of a mix 4,5 nitis, among others. of different grass extracts, each containing several proteins of Allergen-specific immunotherapy (SIT), where the in- different physiochemical properties; however, the subtle contribu- dividual is repeatedly exposed to increasing amounts of tions of each protein are difficult to elucidate. This study aimed to the allergen, resulting in a desensitization to the allergen, is identify and characterize the group 1 and 5 allergens in a 13 grass 6 the only causative allergy treatment to date. Although the extract and to standardize the extraction method. precise underlying immunologic mechanism is yet to be fully Methods: The grass pollens were extracted in isolation and pooled elucidated, an increase in the production of IgG antibodies, and also in combinatio