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action of fibroblast growth factor-2 on the intervertebral disc椎间盘的纤维母细胞生长因子2的行动.pdf

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action of fibroblast growth factor-2 on the intervertebral disc椎间盘的纤维母细胞生长因子2的行动

Available online /content/10/2/R48 Vol 10 No 2 Open Access Research article Action of fibroblast growth factor-2 on the intervertebral disc 1 2 1,2 2 1,2,3 2 Xin Li , Howard S An , Michael Ellman , Frank Phillips , Eugene J Thonar , Daniel K Park , Ranjith K Udayakumar1,2 and Hee-Jeong Im1,2,3 1Department of Biochemistry, Rush University Medical Center, Cohn Research BD 516, 1735 W. Harrison, Chicago, IL 60612, USA 2Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA 3Department of Internal Medicine, Section of Rheumatology, Rush University Medical Center, Chicago, IL 60612, USA Corresponding author: Hee-Jeong Im, hee-jeong_sampen@ Received: 19 Feb 2008 Revisions requested: 14 Mar 2008 Revisions received: 15 Apr 2008 Accepted: 24 Apr 2008 Published: 24 Apr 2008 Arthritis Research Therapy 2008, 10:R48 (doi:10.1186/ar2407) This article is online at: /content/10/2/R48 © 2008 Li et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Fibroblast growth factor 2 (FGF2) is a growth Results The primary receptor expressed in bovine nucleus factor that is immediately released after cartilage injury and plays pulposus cartilage is FGFR1, and this receptor is upregulated in a pivotal role in cartilage homeostasis.