activated protein c increases sensitivity to vasoconstriction in rabbit escherichia coli endotoxin-induced shock活化蛋白c增加敏感性在兔大肠杆菌endotoxin-induced休克血管收缩.pdfVIP
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activated protein c increases sensitivity to vasoconstriction in rabbit escherichia coli endotoxin-induced shock活化蛋白c增加敏感性在兔大肠杆菌endotoxin-induced休克血管收缩
Available online /content/10/2/R47
Vol 10 No 2 Open Access
Research
Activated protein C increases sensitivity to vasoconstriction in
rabbit Escherichia coli endotoxin-induced shock
1,2,3 1,2 1,2 4
Eric Wiel , Marion Elizabeth Costecalde , Gilles Lebuffe , Delphine Corseaux ,
4 1 1,2 1,2
Brigitte Jude , Régis Bordet , Benoît Tavernier and Benoît Vallet
1EA 1046, Laboratory of Pharmacology, University Hospital of Lille, France
2Federation of Research in Anesthesiology and Intensive Care Medicine, University Hospital of Lille, France
3Prehospital Emergency Department (SAMU 59), University Hospital of Lille, France
4EA 2693-INSERM-ESPRI, Laboratory of Hematology, University Hospital of Lille, France
Corresponding author: Eric Wiel, e-wiel@chru-lille.fr
Received: 12 Dec 2005 Revisions requested: 16 Jan 2006 Revisions received: 8 Feb 2006 Accepted: 20 Feb 2006 Published: 15 Mar 2006
Critical Care 2006, 10:R47 (doi:10.1186/cc4858)
This article is online at: /content/10/2/R47
© 2006 Wiel et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Introduction The aim of this study was to investigate the effects nitro-L-arginine methyl ester and not observed in E- rings from
of activated pro
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