药理学2（Pharmacology 2）.docVIP

药理学2（Pharmacology 2） On!! the toxic mechanism of organic phosphorus and rescue measures: the combination of hydroxyl phosphorus atoms in organic phosphate lipid molecules covalently attached to cholinesterase esteratic site complex is formed, and the formation of phosphorylated cholinesterase to hydrolysis, the hydrolysis of Ach lost cholinesterase activity, resulting in the accumulation of the body, produce a series of symptoms of poisoning. If not promptly rescued, poisoning enzymes in a few hours or even minutes to aging and lost the ability to reactivate. Rescue measures: (1) acute poisoning: remove poison poison were removed from the place, and cleaning the skin, gastric lavage and catharsis; symptomatic treatment, oxygen inhalation, artificial respiration, rehydration, vasopressors and anticonvulsants etc.. The use of special drugs, M receptor blocker atropine, moderate and severe poisoning combined with cholinesterase, resurrection drug, phosphorus release. The principle of medication is early, repeated, and sufficient. (2) chronic poisoning, except for strengthening protection, can be symptomatic treatment. On!! organic phosphate poisoning rescue drugs and lipid detoxification principle: atropine, AchE drugs: Atropine: Resurrection principle can be combined with M-R, inhibited Ach binding to the receptor, the anticholinergic effects, to quickly relieve poisoning M like symptoms and signs; relieves symptoms of CNS poisoning; heart rate; blocking the N1-R ganglion, against the N1 like effect. The rise of AchE drugs: such as pralidoxime, phosphoryl and phosphorylation of AchE formed covalent bond, then cleaved into AchE and phosphoryl PAM-CL dissolve AchE activity, thereby restoring; at the same time, can prevent the free poison further combined with AchE, to avoid the poisoning process of development. On!! the similarities and differences between epinephrine and isoproterenol on receptor function, clinical use: AD excited AB receptor, mainly used in clinical c