药理记忆.docVIP

药理记忆 This post is finally edited by brother 2012-5-21 at 17:30 Glucocorticoid summary (memory method, eight, four): 1. structure-activity relationships have four: the basic structure is steroid core 1) the keto group of C3, the carbonyl group of C20 and the double bond of C4-5 are necessary for keeping the physiological function; 2) there is -OH on C17; there is =O or -OH on C11; 3) C1~2 is double bond and C6 introduction of -CH3, the anti-inflammatory effect is enhanced, and the metabolism of water and salt is weakened; 4) when C9 was introduced into -F and C16 was introduced into -CH3 or -OH, the anti-inflammatory effect was stronger and the metabolism of water and salt was weaker. 2., four physiological role: sugar, egg, fat, sodium protection. The 3. is divided into four categories: short acting (coniferous), in effect (Ni Songlei) and long (Mi Songlei) and external (F:) 4. four resistance (super physiological dose): anti-inflammatory, anti allergic, anti shock, anti 5. of the blood and hematopoietic system, a little more than four: 1) eosinophils and lymphocytes -, treatment of acute lymphoblastic leukemia. 2) red blood cells, hemoglobin, aplastic anemia treated??. 3) platelet therapy for thrombocytopenia?. 4) neutropenia, neutropenia. 6. adverse reactions: (1) four one: one in one, one in retreat, one in a slow, one in reverse. 1) one into: type of adrenal hyperfunction (Cushings syndrome). 2) withdrawal: atrophy of adrenal cortex and hypofunction of secretion. 3) a slow: slow healing of the wound. 4) one against: withdrawal rebound phenomenon. (two) four induced: 1) induce or worsen infection. 2) induce or aggravate diabetes mellitus and hypertension. (3) induce or aggravate ulcer disease. 4) inducing or aggravating mental illness. 7. and four usage: 1) small substitution: adrenal hypofunction, etc.. 2) mass assault: severe infection or shock. 3) positive amount of chronic diseases: autoimmune diseases, inflammatory sequelae, etc.. 4) two days a total amount