admissions to intensive care unit of hiv-infected patients in the era of highly active antiretroviral therapy etiology and prognostic factors招生的重症监护病房感染艾滋病毒的病人在高效抗逆转录病毒疗法的时代病因和预后因素.pdfVIP

Chiang et al. Critical Care 2011, 15:R202 /content/15/4/R202 RESEARCH Open Access Admissions to intensive care unit of HIV-infected patients in the era of highly active antiretroviral therapy: etiology and prognostic factors 1 2 3 4 2 2 Hou-Hsien Chiang , Chien-Ching Hung , Chang-Min Lee , Hsuan-Yu Chen , Mao-Yuan Chen , Wang-Huei Sheng , 2 2 5* 5 Szu-Min Hsieh , Hsin-Yun Sun , Chao-Chi Ho and Chong-Jen Yu Abstract Introduction: Although access to highly active antiretroviral therapy (HAART) has prolonged survival and improved life quality, HIV-infected patients with severe immunosuppression or comorbidities may develop complications that require critical care support in intensive care units (ICU). This study aimed to describe the etiology and analyze the prognostic factors of HIV-infected Taiwanese patients in the HAART era. Methods: Medical records of all HIV-infected adults who were admitted to ICU at a university hospital in Taiwan from 2001 to 2010 were reviewed to record information on patient demographics, receipt of HAART, and reason for ICU admission. Factors associated with hospital mortality were analyzed. Results: During the 10-year study period, there were 145 ICU admissions for 135 patients, with respiratory failure being the most common cause (44.4%), followed by sepsis (33.3%) and neurological disease (11.9%). Receipt of HAART was not associated with survival. However, CD4 count was independently predictive of hospital mortality (adjusted odds ratio [AOR], per-10 cells/mm3 decrease, 1.036; 95% confidence interval [CI], 1.003 to 1.069). Admission diagnosis of sepsis was independently