an efficient and chemoselective procedure for acylal synthesis一个高效、chemoselective acylal合成过程.pdfVIP

Molecules 2010, 15, 6493-6501; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article An Efficient and Chemoselective Procedure for Acylal Synthesis 1 1 2 2, Da-He Fan , Hui Wang , Xing-Xing Mao and Yong-Miao Shen * 1 School of Chemical and Biological Engineering, Yancheng Institute of Technology, Yancheng 224003, China 2 Department of Chemistry, Shaoxing University, Shaoxing 312000, China * Author to whom correspondence should be addressed; E-Mail:chemreagent@; Tel.: +86-575 Fax: +86-575 Received: 23 June 2010; in revised form: 6 September 2010 / Accepted: 15 September 2010 / Published: 16 September 2010 Abstract: A novel heterogeneous efficient procedure has been developed for the chemoselective synthesis of acylals (1,1-diacetates) under solvent-free conditions. A novel catalyst prepared by the sulfuric acid catalyzed copolymerization of p -toluenesulfonic acid and paraformaldehyde displays extremely high activities for the title reactions, affording average yields over 90% within several minutes. A comparative study showed that the novel catalyst has much higher activity than other catalysts used for this purpose. Besides, the novel catalyst displays chemoselectivity for the protection of aldehydes in the presence of ketones. In addition the high acidity (4.0 mmol/g), thermal stability (200 ºC) and easy