吲哚美辛片（Indometacin Tablets）.docVIP

吲哚美辛片（Indometacin Tablets） Indometacin Tablets Name used before English name INDOMETACIN TABLETS Pinyin name YINDUOMEIXIN PIAN Antipyretic, analgesic and non steroidal anti-inflammatory and analgesic drugs Character of this product is white. Pharmacology and toxicology, a non steroidal anti-inflammatory drug, has anti-inflammatory, antipyretic and analgesic effects. Its mechanism is to reduce prostaglandin synthesis by inhibiting cyclooxygenase. Inhibit the formation of pain in the inflammatory tissue, nerve impulse, inhibit inflammatory response, including inhibition of chemotaxis of leukocytes and release of lysosomal enzymes. As for the antipyretic effect, due to the effect of the hypothalamic thermoregulatory center, caused by peripheral vasodilation and sweating, increased heat. The central cooling effect may also be prostaglandin synthesis in the hypothalamus inhibited the. Acute toxicity test: the rats were orally LD50 with 12mg/kg, and the oral LD50 was 50mg/kg. Pharmacokinetics, oral absorption, rapid and complete, 4 hours can reach 90% of the dose, food or take aluminum and magnesium acid drugs can slightly slow absorption, plasma protein binding rate of about 99%. Oral administration of 1~4 hours, the peak blood concentration, dosage of 25mg, serum concentration of 1.4 mu g/ml, 50mg is 2.8 mu g/ml; T1/2 average 4.5 hours, preterm infants significantly longer. This product is metabolized to demethylation and demethylation in the liver and can be hydrolyzed to indomethacin and re absorbed and recycled. 60% excretion from the kidneys, 10% to 20% of the prototype excreted; 33% excreted from the bile, of which 1.5% of the prototype medicine; in the milk also has discharge (up to 0.5 ~ 2.0mg per day). This product should not be removed by dialysis. Indications for arthritis are relief of pain and swelling. Injury and inflammation of soft tissue; antipyretic; other: used for the treatment of migraine, dysmenorrhea, postoperative pain, post-traumatic pain, etc..