homocysteine on coronary heart disease risk factors（同型半胱氨酸对冠心病危险因素）.docVIP

Homocysteine on coronary heart disease risk factors [Abstract] Recent studies found that high Hey hyperlipidemia promote the process of coronary atherosclerosis, unlike the traditional risk factors such as hypertension, hyperlipidemia, diabetes, smoking, is an independent risk factor for CHD,. Pathogenesis of Hcy to further explore the high Hcy and coronary artery disease and treatment prospects. [Keywords:] homocysteine #8203;#8203;with coronary heart disease risk factors for disease-causing mechanism Is a sulfur amino acid homocysteine #8203;#8203;(homocysteine.Hcy), is an important intermediate metabolite in the methionine cycle, lack of Hcy metabolism is blocked when the Hcy metabolism-related enzymes or cofactors, will lead the same type of semi- The cystine hyperlipidemia (hyperhomocysteinemic). Mendis, [1] a control study found that coronary heart disease in patients with fasting plasma Hcy was significantly higher than healthy controls, after exclusion of other risk factors, Hcy is still with coronary heart disease was significantly related to serum Hcy elevation was an independent risk factor for coronary heart disease, the development. Physical and chemical properties and metabolism of a same type of cysteine Homocysteine #8203;#8203;Its structural formula is HSCH (NH) co2H, the intermediate product of methionine metabolism. Plasma Hcy exists in three forms: 1% to restore the state free of Hcy, 70% ~ 80% protein binding, and the remaining Hcy disulfide. Plasma total homocysteine #8203;#8203;(tHey) that the three parts of the sum of its in vivo metabolic pathways are as follows: ① The re-methylation pathway: Hcy to vitamin B coenzyme, by accepting the 5 - methylenetetrahydrofolate or betaine methyl provided. Re-synthesis of methionine, 5 - methyl tetrahydrofolate, tetrahydrofolate by 5,10 - methylenetetrahydrofolate reductase (MTHFR) catalytic arising ② turn vulcanized channels: reduction in cystathionine synthase (CBS) and cystathi