线粒体功能异常与肿瘤的生成.pdfVIP

1548 汤春铃 等/线粒体功能异常与肿瘤的生成 生 物 工 程 学 报 Chinese Journal of Biotechnology November 25, 2013, 29(11): 1548−1557 /cjbcn ©2013 Chin J Biotech, All rights reserved 综 述 线粒体功能异常与肿瘤的生成 汤春铃，向仲怀，崔红娟 西南大学 家蚕基因组生物学国家重点实验室，重庆 400716 汤春铃, 向仲怀, 崔红娟. 线粒体功能异常与肿瘤的生成. 生物工程学报, 2013, 29(11): 1548−1557. Tang CL, Xiang ZH, Cui HJ. Essential role of mitochondria in tumorigenesis. Chin J Biotech, 2013, 29(11): 1548−1557. 摘 要: 肿瘤的发生是一个多种信号网络相互参与调节的复杂过程，随着进程的继续，肿瘤细胞逐渐表现出 无限增殖、抵抗凋亡、逃避免疫监督、侵袭与转移以及出现异常的代谢途径等标志性特征。线粒体作为一种独 特的细胞器，其在细胞能量代谢、氧自由基生成和细胞凋亡等过程中的作用都与肿瘤细胞的发生密切相关。文 中就近年来线粒体功能异常在肿瘤发生、形成中所发挥的作用进行综述。 关键词: 肿瘤，线粒体，能量代谢，凋亡，活性氧 Essential role of mitochondria in tumorigenesis Chunling Tang, Zhonghuai Xiang, and Hongjuan Cui State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China Abstract: Tumorigenesis is a complex process that is regulated by a variety of network signals. With the continuous development of the process, tumor cells gradually exhibit lots of hallmarks.Tumor cells have the characteristics of unlimited proliferation, resistance to apoptosis, evading immune surveillance, among others. As a unique organelles, mitochondria play an important role in cellular energy metabolism, reactive oxygen species producing and apoptosis process. Particularly, mitochondria have a close relationship with tumor development. In this review, we focus on the essential role of mitochondria in tumor cells development. Keywords: tumor, mitochondr