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association of hmgb1 polymorphisms with outcome in patients with systemic inflammatory response syndrome协会hmgb1多态性与全身炎症反应综合征患者的结果.pdf

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association of hmgb1 polymorphisms with outcome in patients with systemic inflammatory response syndrome协会hmgb1多态性与全身炎症反应综合征患者的结果

Available online /content/12/3/R83 Vol 12 No 3 Open Access Research Association of HMGB1 polymorphisms with outcome in patients with systemic inflammatory response syndrome 1,2 1 1 3 2 Brian Kornblit , Lea Munthe-Fog , Hans O Madsen , Jens Strøm , Lars Vindeløv and Peter Garred1 1Department of Clinical Immunology – 7631, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen O, Denmark 2The Allogeneic Hematopoietic Cell Transplantation Laboratory – 4041, Department of Haematology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen O, Denmark 3Department of Research, Sygehus Sønderjylland, University of Southern Denmark, 6200 Aabenraa, Denmark Corresponding author: Brian Kornblit, brian.kornblit@rh.regionh.dk Received: 30 Mar 2008 Revisions requested: 22 Apr 2008 Revisions received: 13 May 2008 Accepted: 24 Jun 2008 Published: 24 Jun 2008 Critical Care 2008, 12:R83 (doi:10.1186/cc6935) This article is online at: /content/12/3/R83 © 2008 Kornblit et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction High mobility group box 1 protein (HMGB1) is a Results Homozygosity and heterozygosity for a promoter variant pleiotropic cytokine, recently implicated in the pathophysiology (-1377delA) was associated with a decreased overall 4-year of the systemic inflammatory re