原创力文档cardiovascular and renal effects of carperitide and nesiritide in cardiovascular surgery patients a systematic review and meta-analysis心血管和肾脏carperitide和nesiritide心血管手术患者的系统回顾和荟萃分析.pdfVIP
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cardiovascular and renal effects of carperitide and nesiritide in cardiovascular surgery patients a systematic review and meta-analysis心血管和肾脏carperitide和nesiritide心血管手术患者的系统回顾和荟萃分析
Mitaka et al. Critical Care 2011, 15:R258
/content/15/5/R258
RESEARCH Open Access
Cardiovascular and renal effects of carperitide
and nesiritide in cardiovascular surgery patients:
a systematic review and meta-analysis
1* 2 2 3
Chieko Mitaka , Toshifumi Kudo , Go Haraguchi and Makoto Tomita
Abstract
Introduction: Acute kidney injury (AKI) following cardiovascular surgery is a common disease process and is
associated with both morbidity and mortality. The aim of our study was to evaluate the cardiovascular and renal
effects of an atrial natriuretic peptide (ANP, carperitide) and a B-type (or brain) natriuretic peptide (BNP, nesiritide)
for preventing and treating AKI in cardiovascular surgery patients.
Methods: Electronic databases, including PubMed, EMBASE and references from identified articles were used for a
literature search.
Results: Data on the infusion of ANP or BNP in cardiovascular surgery patients was collected from fifteen
randomized controlled trials and combined. The infusion of ANP or BNP increased the urine output and creatinine
clearance or glomerular filtration rate, and reduced the use of diuretics and the serum creatinine levels. A meta-
analysis showed that ANP infusion significantly decreased peak serum creatinine levels, incidence of arrhythmia
and renal replacement therapy. The meta-analysis also showed that ANP or BNP infusion significantly decreased
the length of ICU stay and hospital stay compared with controls. However, the combined data were insufficient to
determine how ANP or BNP infusion during the perioperative period influences long-term outcome in
cardiovascular surgery patients.
Conclusions: The infusion of ANP or BNP may preserve postoperative renal function in cardiova
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