原创力文档chromatin regulated interchange between polycomb repressive complex 2 (prc2)-ezh2 and prc2-ezh1 complexes controls myogenin activation in skeletal muscle cells染色质调节之间的交换polycomb压制复杂2(prc2)-ezh2 prc2-ezh1复合物控制myogenin激活骨骼肌细胞.pdfVIP
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chromatin regulated interchange between polycomb repressive complex 2 (prc2)-ezh2 and prc2-ezh1 complexes controls myogenin activation in skeletal muscle cells染色质调节之间的交换polycomb压制复杂2(prc2)-ezh2 prc2-ezh1复合物控制myogenin激活骨骼肌细胞
Stojic et al. Epigenetics Chromatin 2011, 4:16
/content/4/1/16
RESEARCH Open Access
Chromatin regulated interchange between
polycomb repressive complex 2 (PRC2)-Ezh2 and
PRC2-Ezh1 complexes controls myogenin
activation in skeletal muscle cells
1,2† 1,3† 1† 4 1,5
Lovorka Stojic , Zuzana Jasencakova , Carolina Prezioso , Alexandra Stützer , Beatrice Bodega ,
3,6 7 1,8 9 1,10 7
Diego Pasini , Rebecca Klingberg , Chiara Mozzetta , Raphael Margueron , Pier Lorenzo Puri , Dirk Schwarzer ,
Kristian Helin3, Wolfgang Fischle4 and Valerio Orlando1*
Abstract
Background: Polycomb group (PcG) genes code for chromatin multiprotein complexes that are responsible for
maintaining gene silencing of transcriptional programs during differentiation and in adult tissues. Despite the large
amount of information on PcG function during development and cell identity homeostasis, little is known
regarding the dynamics of PcG complexes and their role during terminal differentiation.
Results: We show that two distinct polycomb repressive complex (PRC)2 complexes contribute to skeletal muscle
cell differentiation: the PRC2-Ezh2 complex, which is bound to the myogenin (MyoG) promoter and muscle creatine
kinase (mCK) enhancer in proliferating myoblasts, and the PRC2-Ezh1 complex, which replaces PRC2-Ezh2 on MyoG
promoter in post-mitotic myotubes. Interestingly, the opposing dynamics of PRC2-Ezh2 and PRC2-Ezh1 at these
muscle regulatory regions is differentially regulated at the chromatin level by Msk1 dependent methyl/phospho
switch mechanism involving phosphorylation
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