comparison of four statistical methods for detection of a major gene in a progeny test design比较四种统计方法检测的主要基因在后代测试设计.pdfVIP

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comparison of four statistical methods for detection of a major gene in a progeny test design比较四种统计方法检测的主要基因在后代测试设计.pdf

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comparison of four statistical methods for detection of a major gene in a progeny test design比较四种统计方法检测的主要基因在后代测试设计

Original article Comparison of four statistical methods for detection of a major gene in a progeny test design P. Le Roy J.M. Elsen1 S. Knott2 Institut1National de la Recherche Agronomique, centre de recherches de Toulouse, station d’amélioration génétique des animaux, Auzeville 31.i26 Castanet-Tolosan Cedex, France 2 AFRC, IAPGR, Edinburgh Research Station, Roslin, Midlothian, EH 25 9PS, UK (received 17 August 1988, accepted 23 January 1989) Summary - In livestock improvement it is common to design a progeny test of sires in order to estimate their breeding values. The data recorded for these estimate are useful for the detection of major genes. They are the n.m performances Yg! of m progeny j of n sires i. These data need to be corrected for the polygenic influence of the sire on its progeny (sire i effect U).iFour statistical tests of the segregation of a major gene are compared. The first SA(Ifor segregation analysis) is the classical ratio of the likelihoods under Ho (no major gene) and Hi (a major gene is segregating). The parameters describing the population (meansand standard deviations within genotype) are estimated by maximizing the marginal likelihood of the Yij. The other statistics studied are approximations of this SAIstatistic where the sire i effect Z)(Uis considered as a fixed effect FE(lstatistic) or, following Elsen et al. (1988) and H6schele (1988), where the parameters, and Ui, are estimated maximizing the joint likelihood of Ui and and ME2I Yij ME(l, statistics). Simulation studies were done in order to describe the distribution of these statistics. It is shown that and are the most followed whose relative loss SAI ME1, powerful test, by M