conditions in subjects with rheumatic diseases pulmonary manifestations of vasculitides环境学科与风湿性疾病肺vasculitides的表现.pdfVIP

Holle et al. Arthritis Research Therapy 2011, 13:224 /content/13/3/224 R E V I E W Conditions in subjects with rheumatic diseases: pulmonary manifestations of vasculitides 1 1 2 1 Julia U Holle* , Frank Moosig , Klaus Dalhof and Wolfgang L Gross infl ammatory mass formation (‘granuloma tous disease’), Abstract which is most prevalent in the upper and lower Pulmonary involvement is a common complication respiratory tracts and characterized by tumor-like infi l- of vasculitides, especially small vessel vasculitides. trative or destructive disease. In CSS, ‘granuloma forma- This review provides an overview of vasculitic tion’ may also be found, though less pronounced; manifestations of the lung as well as of other organs furthermore, asthma, hypereosinophilia and eosinophilic involved in vasculitides. Furthermore, it provides the organ infi ltration are hallmarks of CSS. diagnostic procedures required to asses a patient with vasculitic lung involvement and gives an overview of Wegener’s granulomatosis current treatment strategies. Clinical features and histology From the clinical point of view, WG is characterized by two features: mass formation and ANCA-associated Introduction small- to med